HINFP
histone H4 transcription factor | DKFZP434F162, HiNF-P, ZNF743, MIZF

This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]

Biological processes 42 terms
Cajal body (GO:0015030)DNA binding (GO:0003677)DNA damage checkpoint signaling (GO:0000077)DNA repair (GO:0006281)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-templated transcription (GO:0006351)G1/S transition of mitotic cell cycle (GO:0000082)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)cell cycle G1/S phase transition (GO:0044843)chromatin binding (GO:0003682)enzyme binding (GO:0019899)establishment of protein localization (GO:0045184)histone binding (GO:0042393)in utero embryonic development (GO:0001701)in utero embryonic development (GO:0001701)myoblast differentiation (GO:0045445)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of gene expression (GO:0010629)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of gene expression (GO:0010628)positive regulation of gene expression (GO:0010628)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)transcription cis-regulatory region binding (GO:0000976)
Expression (TPM)
HINFP — as a Regulated Gene

TFs regulating HINFP 0 TFs

Transcription factors with Perturb-seq knockdown data for HINFP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HINFP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to HINFP

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HINFP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:118,907,074–118,907,685 214.3 kb Distal (>10kb) Multiome 491
chr11:118,909,181–118,909,816 212.2 kb Distal (>10kb) Multiome 326
chr11:118,909,976–118,911,609 210.9 kb Distal (>10kb) Multiome 652
chr11:118,911,717–118,912,963 209.3 kb Distal (>10kb) Multiome 689
chr11:118,916,429–118,917,335 204.6 kb Distal (>10kb) Multiome 355
chr11:118,917,640–118,918,851 203.1 kb Distal (>10kb) Multiome 522
chr11:118,925,703–118,926,356 195.5 kb Distal (>10kb) Multiome 595
chr11:118,927,947–118,930,852 192.1 kb Distal (>10kb) Multiome 892
chr11:118,997,538–118,998,797 123.5 kb Distal (>10kb) Multiome 798
chr11:119,018,081–119,019,265 103.0 kb Distal (>10kb) Multiome 897
chr11:119,029,885–119,031,330 90.7 kb Distal (>10kb) Multiome 876
chr11:119,056,436–119,057,778 64.3 kb Distal (>10kb) Multiome 815
chr11:119,067,446–119,068,100 53.8 kb Distal (>10kb) Multiome 762
chr11:119,084,563–119,085,756 36.6 kb Distal (>10kb) Multiome 846
chr11:119,093,969–119,096,070 26.0 kb Distal (>10kb) Multiome 1046
chr11:119,101,351–119,102,791 19.4 kb Distal (>10kb) Multiome 871
chr11:119,106,906–119,107,993 14.3 kb Distal (>10kb) Multiome 650
chr11:119,120,857–119,122,037 117 bp At TSS Multiome 787
chr11:119,144,795–119,145,355 23.5 kb Distal (>10kb) Multiome 230
chr11:119,148,816–119,149,933 28.0 kb Distal (>10kb) Multiome 262
chr11:119,168,601–119,169,645 47.3 kb Distal (>10kb) Multiome 794
chr11:119,205,241–119,207,150 84.5 kb Distal (>10kb) Multiome 695
chr11:119,315,017–119,315,819 193.8 kb Distal (>10kb) Multiome 270
chr11:119,316,693–119,317,760 195.6 kb Distal (>10kb) Multiome 463
chr11:119,320,617–119,321,906 200.2 kb Distal (>10kb) Multiome 516
chr11:119,334,140–119,334,815 212.8 kb Distal (>10kb) Multiome 577
chr11:119,337,716–119,338,797 216.7 kb Distal (>10kb) Multiome 412
chr11:119,339,587–119,340,902 218.6 kb Distal (>10kb) Multiome 477
chr11:119,356,332–119,357,013 235.2 kb Distal (>10kb) Multiome 366
chr11:119,361,041–119,361,699 239.8 kb Distal (>10kb) Multiome 431
chr11:119,363,939–119,364,561 242.6 kb Distal (>10kb) Multiome 255
chr11:119,377,954–119,379,307 257.0 kb Distal (>10kb) Multiome 307
chr11:119,380,894–119,382,060 260.1 kb Distal (>10kb) Multiome 800

Genome Browser

Genomic view of the HINFP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:118,897,074 – 119,392,060
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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