Transcription factors with Perturb-seq knockdown data for HILPDA-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HILPDA-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HILPDA-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:128,453,519–128,453,932 | 2.0 kb | Proximal (<10kb) | 29 | |
| chr7:128,454,251–128,454,939 | 996 bp | At TSS | 220 | |
| chr7:128,455,301–128,456,353 | at TSS | At TSS | 875 | |
| chr7:128,459,404–128,459,602 | 3.5 kb | Proximal (<10kb) | 187 |
Genomic view of the HILPDA-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.