This gene encodes a protein that belongs to the glucose/sorbosone dehydrogenase family. The encoded protein also contains a domain that binds folate and reduced folic acid derivatives. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for HHIPL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HHIPL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HHIPL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:99,479,847–99,482,007 | 164.0 kb | Distal (>10kb) Multiome | 803 | |
| chr14:99,602,979–99,605,771 | 40.7 kb | Distal (>10kb) Multiome | 993 | |
| chr14:99,644,882–99,645,576 | at TSS | At TSS | 169 | |
| chr14:99,663,812–99,664,749 | 19.1 kb | Distal (>10kb) Multiome | 215 | |
| chr14:99,682,774–99,684,994 | 39.0 kb | Distal (>10kb) Multiome | 763 | |
| chr14:99,729,847–99,731,033 | 85.1 kb | Distal (>10kb) Multiome | 551 | |
| chr14:99,792,691–99,793,898 | 148.2 kb | Distal (>10kb) Multiome | 378 |
Genomic view of the HHIPL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.