Enables beta-N-acetylhexosaminidase activity. Predicted to be involved in carbohydrate metabolic process. Located in extracellular vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HEXD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HEXD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HEXD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:82,212,405–82,213,592 | 205.5 kb | Distal (>10kb) Multiome | 911 | |
| chr17:82,228,266–82,232,536 | 189.4 kb | Distal (>10kb) Multiome | 1048 | |
| chr17:82,272,608–82,274,062 | 144.7 kb | Distal (>10kb) Multiome | 943 | |
| chr17:82,278,488–82,279,226 | 139.4 kb | Distal (>10kb) Multiome | 229 | |
| chr17:82,292,400–82,293,256 | 125.4 kb | Distal (>10kb) Multiome | 944 | |
| chr17:82,414,581–82,415,044 | 3.5 kb | Proximal (<10kb) Multiome | 799 | |
| chr17:82,417,993–82,419,018 | 159 bp | At TSS Multiome | 844 | |
| chr17:82,450,369–82,451,002 | 32.5 kb | Distal (>10kb) Multiome | 837 | |
| chr17:82,458,067–82,459,318 | 40.2 kb | Distal (>10kb) Multiome | 1054 | |
| chr17:82,494,122–82,495,128 | 76.4 kb | Distal (>10kb) Multiome | 1010 | |
| chr17:82,496,968–82,497,781 | 79.0 kb | Distal (>10kb) Multiome | 613 | |
| chr17:82,519,154–82,520,226 | 101.2 kb | Distal (>10kb) Multiome | 869 | |
| chr17:82,647,682–82,648,684 | 230.3 kb | Distal (>10kb) Multiome | 874 | |
| chr17:82,697,983–82,699,271 | 280.5 kb | Distal (>10kb) Multiome | 623 | |
| chr17:82,715,983–82,717,178 | 298.2 kb | Distal (>10kb) Multiome | 744 |
Genomic view of the HEXD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.