HERC6

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | FLJ20637

HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

Biological processes 10 terms

cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-protein transferase activity (GO:0004842)

Expression (TPM)

TFs regulating HERC6 0 TFs

Transcription factors with Perturb-seq knockdown data for HERC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HERC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HERC6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HERC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr4:88,112,943–88,113,755	265.7 kb	Distal (>10kb) Multiome	47
chr4:88,158,357–88,159,406	220.1 kb	Distal (>10kb) Multiome	719
chr4:88,178,032–88,179,178	200.6 kb	Distal (>10kb) Multiome	219
chr4:88,283,347–88,285,223	94.3 kb	Distal (>10kb) Multiome	864
chr4:88,378,676–88,379,604	95 bp	At TSS Multiome	741
chr4:88,456,441–88,457,951	78.0 kb	Distal (>10kb) Multiome	865
chr4:88,523,195–88,524,307	144.7 kb	Distal (>10kb) Multiome	927
chr4:88,591,644–88,593,513	213.3 kb	Distal (>10kb) Multiome	832

Genome Browser

Genomic view of the HERC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.