HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for HELQ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HELQ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HELQ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:83,283,973–83,285,305 | 171.2 kb | Distal (>10kb) Multiome | 879 | |
| chr4:83,334,415–83,335,295 | 120.9 kb | Distal (>10kb) Multiome | 455 | |
| chr4:83,455,343–83,456,320 | 55 bp | At TSS Multiome | 983 | |
| chr4:83,484,511–83,485,585 | 29.3 kb | Distal (>10kb) Multiome | 905 | |
| chr4:83,535,410–83,536,979 | 80.5 kb | Distal (>10kb) Multiome | 690 | |
| chr4:83,589,080–83,590,013 | 133.7 kb | Distal (>10kb) Multiome | 157 |
Genomic view of the HELQ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.