This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HECA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HECA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HECA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:138,890,955–138,892,013 | 243.6 kb | Distal (>10kb) Multiome | 99 | |
| chr6:138,987,166–138,988,932 | 146.8 kb | Distal (>10kb) Multiome | 1012 | |
| chr6:139,010,370–139,011,354 | 124.2 kb | Distal (>10kb) Multiome | 168 | |
| chr6:139,028,353–139,030,017 | 106.3 kb | Distal (>10kb) Multiome | 798 | |
| chr6:139,124,987–139,125,193 | 9.9 kb | Proximal (<10kb) | 237 | |
| chr6:139,134,756–139,136,229 | 13 bp | At TSS Multiome | 714 | |
| chr6:139,219,088–139,219,883 | 84.4 kb | Distal (>10kb) Multiome | 525 | |
| chr6:139,313,822–139,314,248 | 178.8 kb | Distal (>10kb) Multiome | 100 | |
| chr6:139,367,489–139,368,506 | 232.9 kb | Distal (>10kb) Multiome HiCAR | 208 | |
| chr6:139,372,852–139,376,242 | 240.4 kb | Distal (>10kb) Multiome | 1354 |
Genomic view of the HECA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.