Predicted to enable oxidoreductase activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HEATR4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HEATR4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HEATR4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:73,237,315–73,238,355 | 254.0 kb | Distal (>10kb) Multiome | 296 | |
| chr14:73,457,486–73,459,145 | 33.1 kb | Distal (>10kb) Multiome | 720 | |
| chr14:73,490,604–73,491,982 | 798 bp | At TSS Multiome | 866 | |
| chr14:73,569,145–73,570,199 | 77.6 kb | Distal (>10kb) Multiome | 680 | |
| chr14:73,591,810–73,592,493 | 100.4 kb | Distal (>10kb) Multiome | 259 | |
| chr14:73,612,266–73,613,237 | 120.9 kb | Distal (>10kb) Multiome | 521 | |
| chr14:73,633,521–73,634,788 | 142.6 kb | Distal (>10kb) Multiome | 541 | |
| chr14:73,644,535–73,645,291 | 153.1 kb | Distal (>10kb) Multiome | 667 | |
| chr14:73,713,545–73,714,769 | 222.5 kb | Distal (>10kb) Multiome | 759 | |
| chr14:73,718,770–73,719,334 | 227.3 kb | Distal (>10kb) Multiome | 138 | |
| chr14:73,759,247–73,760,633 | 268.5 kb | Distal (>10kb) Multiome | 912 | |
| chr14:73,771,644–73,772,269 | 280.2 kb | Distal (>10kb) Multiome | 846 | |
| chr14:73,786,685–73,787,517 | 295.4 kb | Distal (>10kb) Multiome | 497 |
Genomic view of the HEATR4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.