Predicted to enable hydrolase activity. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HDHD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HDHD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HDHD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:113,150,622–113,151,556 | 226.0 kb | Distal (>10kb) Multiome | 705 | |
| chr9:113,220,980–113,222,241 | 155.5 kb | Distal (>10kb) Multiome | 819 | |
| chr9:113,274,845–113,275,974 | 101.4 kb | Distal (>10kb) Multiome | 852 | |
| chr9:113,331,229–113,332,031 | 45.2 kb | Distal (>10kb) Multiome | 69 | |
| chr9:113,339,770–113,340,691 | 36.7 kb | Distal (>10kb) Multiome | 941 | |
| chr9:113,349,409–113,349,994 | 27.3 kb | Distal (>10kb) Multiome | 358 | |
| chr9:113,376,590–113,377,575 | 46 bp | At TSS Multiome | 710 | |
| chr9:113,400,912–113,402,007 | 24.4 kb | Distal (>10kb) Multiome | 859 | |
| chr9:113,409,973–113,410,921 | 33.6 kb | Distal (>10kb) Multiome | 997 | |
| chr9:113,463,361–113,464,008 | 86.7 kb | Distal (>10kb) Multiome | 526 | |
| chr9:113,541,084–113,541,543 | 164.4 kb | Distal (>10kb) Multiome | 160 | |
| chr9:113,591,435–113,592,161 | 214.8 kb | Distal (>10kb) Multiome | 345 | |
| chr9:113,593,578–113,594,410 | 217.0 kb | Distal (>10kb) Multiome | 433 | |
| chr9:113,634,469–113,635,132 | 257.8 kb | Distal (>10kb) Multiome | 142 | |
| chr9:113,658,015–113,658,473 | 281.2 kb | Distal (>10kb) Multiome | 307 |
Genomic view of the HDHD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.