This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
Transcription factors with Perturb-seq knockdown data for HDAC11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HDAC11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HDAC11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:13,281,536–13,283,868 | 197.2 kb | Distal (>10kb) Multiome | 567 | |
| chr3:13,301,084–13,301,878 | 178.7 kb | Distal (>10kb) Multiome | 345 | |
| chr3:13,419,449–13,420,954 | 60.0 kb | Distal (>10kb) Multiome | 719 | |
| chr3:13,451,423–13,452,307 | 28.3 kb | Distal (>10kb) Multiome | 750 | |
| chr3:13,479,315–13,481,211 | 12 bp | At TSS Multiome | 821 | |
| chr3:13,496,355–13,496,596 | at TSS | At TSS | 253 | |
| chr3:13,500,203–13,500,403 | 3.6 kb | Proximal (<10kb) | 108 | |
| chr3:13,546,672–13,547,232 | 66.8 kb | Distal (>10kb) Multiome | 324 | |
| chr3:13,548,548–13,549,592 | 68.9 kb | Distal (>10kb) Multiome | 246 | |
| chr3:13,595,157–13,596,271 | 115.5 kb | Distal (>10kb) Multiome | 155 | |
| chr3:13,648,109–13,648,809 | 168.3 kb | Distal (>10kb) Multiome HiCAR | 456 | |
| chr3:13,650,360–13,650,812 | 170.4 kb | Distal (>10kb) Multiome HiCAR | 720 | |
| chr3:13,655,106–13,655,809 | 175.3 kb | Distal (>10kb) Multiome HiCAR | 273 |
Genomic view of the HDAC11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.