HCLS1

hematopoietic cell-specific Lyn substrate 1 | CTTNL, HS1

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; protein kinase binding activity; and signaling adaptor activity. Involved in several processes, including granulocyte colony-stimulating factor signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of protein import into nucleus. Located in cytosol; nucleus; and plasma membrane. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 42 terms

RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)SH3 domain binding (GO:0017124)actin filament binding (GO:0051015)actin filament organization (GO:0007015)cellular response to cytokine stimulus (GO:0071345)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)endocytic vesicle (GO:0030139)erythrocyte differentiation (GO:0030218)erythrocyte differentiation (GO:0030218)granulocyte colony-stimulating factor signaling pathway (GO:0038158)intracellular signal transduction (GO:0035556)membrane (GO:0016020)mitochondrion (GO:0005739)negative regulation of leukocyte apoptotic process (GO:2000107)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear transport (GO:0051169)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)positive regulation of cell population proliferation (GO:0008284)positive regulation of cell population proliferation (GO:0008284)positive regulation of granulocyte differentiation (GO:0030854)positive regulation of granulocyte differentiation (GO:0030854)positive regulation of macrophage differentiation (GO:0045651)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)positive regulation of protein import into nucleus (GO:0042307)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein-containing complex binding (GO:0044877)regulation of DNA-templated transcription (GO:0006355)regulation of actin filament polymerization (GO:0030833)response to hormone (GO:0009725)response to hormone (GO:0009725)signal transduction (GO:0007165)signaling adaptor activity (GO:0035591)transcription regulator complex (GO:0005667)

Expression (TPM)