HCK

HCK proto-oncogene, Src family tyrosine kinase | JTK9

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

Biological processes 68 terms

ATP binding (GO:0005524)Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)Golgi apparatus (GO:0005794)actin filament (GO:0005884)caveola (GO:0005901)caveola (GO:0005901)cell adhesion (GO:0007155)cell differentiation (GO:0030154)cell surface receptor protein tyrosine kinase signaling pathway (GO:0007169)cellular response to lipid (GO:0071396)cytokine-mediated signaling pathway (GO:0019221)cytoplasmic side of plasma membrane (GO:0009898)cytoplasmic side of plasma membrane (GO:0009898)cytoplasmic vesicle (GO:0031410)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)defense response (GO:0006952)focal adhesion (GO:0005925)focal adhesion (GO:0005925)innate immune response-activating signaling pathway (GO:0002758)innate immune response-activating signaling pathway (GO:0002758)integrin-mediated signaling pathway (GO:0007229)intracellular signal transduction (GO:0035556)intracellular signal transduction (GO:0035556)leukocyte degranulation (GO:0043299)leukocyte migration (GO:0050900)leukocyte migration involved in immune response (GO:0002522)lipid binding (GO:0008289)lipopolysaccharide-mediated signaling pathway (GO:0031663)lysosome (GO:0005764)lysosome (GO:0005764)membrane (GO:0016020)membrane raft (GO:0045121)mesoderm development (GO:0007498)negative regulation of apoptotic process (GO:0043066)negative regulation of inflammatory response to antigenic stimulus (GO:0002862)negative regulation of inflammatory response to antigenic stimulus (GO:0002862)non-membrane spanning protein tyrosine kinase activity (GO:0004715)non-membrane spanning protein tyrosine kinase activity (GO:0004715)nucleus (GO:0005634)peptidyl-tyrosine phosphorylation (GO:0018108)phosphotyrosine residue binding (GO:0001784)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of actin filament polymerization (GO:0030838)positive regulation of cell population proliferation (GO:0008284)positive regulation of cell population proliferation (GO:0008284)protein autophosphorylation (GO:0046777)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein phosphorylation (GO:0006468)protein tyrosine kinase activity (GO:0004713)protein tyrosine kinase activity (GO:0004713)protein tyrosine kinase activity (GO:0004713)protein tyrosine kinase activity (GO:0004713)regulation of actin cytoskeleton organization (GO:0032956)regulation of cell shape (GO:0008360)regulation of inflammatory response (GO:0050727)regulation of phagocytosis (GO:0050764)regulation of podosome assembly (GO:0071801)respiratory burst after phagocytosis (GO:0045728)signaling receptor binding (GO:0005102)transport vesicle (GO:0030133)type II interferon-mediated signaling pathway (GO:0060333)

Expression (TPM)