The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for HAVCR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HAVCR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HAVCR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:155,883,796–155,884,682 | 1258.7 kb | Distal (>10kb) Multiome HiCAR | 165 | |
| chr5:157,033,210–157,035,082 | 108.2 kb | Distal (>10kb) Multiome | 216 | |
| chr5:157,142,257–157,143,974 | 12 bp | At TSS Multiome | 801 | |
| chr5:157,148,714–157,149,175 | 5.8 kb | Proximal (<10kb) | 297 | |
| chr5:157,265,417–157,267,113 | 123.3 kb | Distal (>10kb) Multiome HiCAR | 565 | |
| chr5:157,328,291–157,328,932 | 185.7 kb | Distal (>10kb) Multiome | 311 |
Genomic view of the HAVCR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.