The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for HAUS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HAUS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HAUS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:42,273,010–42,273,873 | 275.4 kb | Distal (>10kb) Multiome | 883 | |
| chr15:42,490,811–42,491,337 | 57.7 kb | Distal (>10kb) Multiome | 807 | |
| chr15:42,548,416–42,549,113 | 95 bp | At TSS Multiome | 848 | |
| chr15:42,575,082–42,575,846 | 26.6 kb | Distal (>10kb) Multiome | 785 | |
| chr15:42,736,813–42,737,498 | 188.3 kb | Distal (>10kb) Multiome | 576 |
Genomic view of the HAUS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.