Predicted to be involved in positive regulation of gene expression. Predicted to act upstream of or within with a positive effect on cardiac right ventricle morphogenesis. Predicted to act upstream of or within transcription elongation by RNA polymerase II. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HAND2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HAND2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HAND2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:173,516,522–173,517,418 | 9.8 kb | Proximal (<10kb) | 182 | |
| chr4:173,517,533–173,518,354 | 8.9 kb | Proximal (<10kb) | 112 | |
| chr4:173,518,462–173,519,114 | 8.2 kb | Proximal (<10kb) | 140 | |
| chr4:173,521,529–173,524,247 | 3.0 kb | Proximal (<10kb) | 413 | |
| chr4:173,524,610–173,525,886 | 1.4 kb | Proximal (<10kb) | 224 | |
| chr4:173,526,721–173,528,011 | at TSS | At TSS | 247 | |
| chr4:173,528,309–173,531,024 | 1.0 kb | Proximal (<10kb) | 426 | |
| chr4:173,531,197–173,532,084 | 3.9 kb | Proximal (<10kb) | 195 | |
| chr4:173,536,826–173,537,384 | 9.6 kb | Proximal (<10kb) | 119 | |
| chr4:173,537,707–173,539,114 | 9.0 kb | Proximal (<10kb) | 380 |
Genomic view of the HAND2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.