H2AC8
H2A clustered histone 8 | H2A.1, H2A/a, H2AFA, HIST1H2AE

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Biological processes 21 terms
DNA binding (GO:0003677)DNA binding (GO:0003677)chromatin organization (GO:0006325)chromosome (GO:0005694)extracellular exosome (GO:0070062)heterochromatin formation (GO:0031507)negative regulation of cell population proliferation (GO:0008285)nucleoplasm (GO:0005654)nucleosome (GO:0000786)nucleosome (GO:0000786)nucleosome (GO:0000786)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein localization to CENP-A containing chromatin (GO:0061644)structural constituent of chromatin (GO:0030527)structural constituent of chromatin (GO:0030527)structural constituent of chromatin (GO:0030527)
Expression (TPM)
H2AC8 — as a Regulated Gene

TFs regulating H2AC8 0 TFs

Transcription factors with Perturb-seq knockdown data for H2AC8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = H2AC8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to H2AC8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of H2AC8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr6:25,992,391–25,993,479 224.2 kb Distal (>10kb) Multiome 1012
chr6:26,020,104–26,022,401 196.6 kb Distal (>10kb) Multiome 920
chr6:26,025,866–26,027,859 190.6 kb Distal (>10kb) Multiome 1194
chr6:26,031,341–26,032,990 184.8 kb Distal (>10kb) Multiome 1083
chr6:26,033,113–26,034,309 183.2 kb Distal (>10kb) Multiome 800
chr6:26,054,926–26,057,287 161.6 kb Distal (>10kb) Multiome 1174
chr6:26,087,383–26,088,017 129.2 kb Distal (>10kb) Multiome 572
chr6:26,103,452–26,105,109 113.0 kb Distal (>10kb) Multiome 1169
chr6:26,122,481–26,124,909 94.0 kb Distal (>10kb) Multiome 1216
chr6:26,125,788–26,126,592 90.7 kb Distal (>10kb) Multiome 670
chr6:26,156,184–26,158,744 58.9 kb Distal (>10kb) Multiome 1310
chr6:26,171,798–26,172,499 44.9 kb Distal (>10kb) Multiome 580
chr6:26,183,128–26,184,377 33.2 kb Distal (>10kb) Multiome 311
chr6:26,187,874–26,189,538 27.8 kb Distal (>10kb) Multiome 1053
chr6:26,196,695–26,197,676 19.6 kb Distal (>10kb) Multiome 842
chr6:26,198,203–26,200,197 17.5 kb Distal (>10kb) Multiome 939
chr6:26,203,791–26,205,119 12.5 kb Distal (>10kb) Multiome 1071
chr6:26,214,872–26,218,468 62 bp At TSS Multiome 1096
chr6:26,223,716–26,224,480 7.1 kb Proximal (<10kb) Multiome 507
chr6:26,224,856–26,226,566 8.3 kb Proximal (<10kb) Multiome 451
chr6:26,239,944–26,240,920 23.4 kb Distal (>10kb) Multiome 375
chr6:26,249,682–26,251,138 33.4 kb Distal (>10kb) Multiome 731
chr6:26,251,339–26,252,079 34.8 kb Distal (>10kb) Multiome 445
chr6:26,270,815–26,273,967 56.0 kb Distal (>10kb) Multiome 742
chr6:26,285,011–26,286,121 68.6 kb Distal (>10kb) Multiome 1121
chr6:26,304,972–26,305,585 88.5 kb Distal (>10kb) Multiome 586
chr6:26,312,505–26,313,475 96.1 kb Distal (>10kb) Multiome 896
chr6:26,322,092–26,323,232 105.7 kb Distal (>10kb) Multiome 811
chr6:26,327,476–26,328,318 111.2 kb Distal (>10kb) Multiome 716
chr6:26,341,545–26,342,139 124.9 kb Distal (>10kb) Multiome 716
chr6:26,365,073–26,365,647 148.4 kb Distal (>10kb) Multiome 587
chr6:26,382,957–26,383,951 166.3 kb Distal (>10kb) Multiome 448
chr6:26,421,258–26,421,866 204.5 kb Distal (>10kb) Multiome 473
chr6:26,457,390–26,458,395 241.0 kb Distal (>10kb) Multiome 525
chr6:26,473,842–26,474,357 257.2 kb Distal (>10kb) Multiome 487
chr6:27,131,467–27,132,107 914.8 kb Distal (>10kb) Multiome HiCAR 580
chr6:27,132,200–27,134,276 916.0 kb Distal (>10kb) Multiome HiCAR 975
chr6:27,139,091–27,140,128 922.5 kb Distal (>10kb) Multiome HiCAR 662
chr6:27,145,480–27,148,111 930.1 kb Distal (>10kb) Multiome HiCAR 951
chr6:27,752,061–27,752,956 1535.4 kb Distal (>10kb) Multiome HiCAR 499
chr6:27,753,073–27,753,588 1536.4 kb Distal (>10kb) Multiome HiCAR 758
chr6:27,791,916–27,792,609 1575.5 kb Distal (>10kb) Multiome HiCAR 728
chr6:27,806,645–27,808,975 1591.1 kb Distal (>10kb) Multiome HiCAR 963
chr6:27,809,816–27,810,576 1593.2 kb Distal (>10kb) Multiome HiCAR 914
chr6:27,813,688–27,816,146 1598.0 kb Distal (>10kb) Multiome HiCAR 564
chr6:27,836,792–27,839,128 1621.5 kb Distal (>10kb) Multiome HiCAR 1131
chr6:27,865,093–27,868,152 1648.4 kb Distal (>10kb) Multiome HiCAR 744
chr6:27,870,957–27,872,527 1655.3 kb Distal (>10kb) Multiome HiCAR 426
chr6:27,872,808–27,873,995 1656.7 kb Distal (>10kb) Multiome HiCAR 372

Genome Browser

Genomic view of the H2AC8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr6:25,982,391 – 27,883,995
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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