Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for H2AC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = H2AC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of H2AC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:25,992,391–25,993,479 | 206.6 kb | Distal (>10kb) Multiome | 1012 | |
| chr6:26,020,104–26,022,401 | 178.9 kb | Distal (>10kb) Multiome | 920 | |
| chr6:26,025,866–26,027,859 | 173.0 kb | Distal (>10kb) Multiome | 1194 | |
| chr6:26,031,341–26,032,990 | 167.1 kb | Distal (>10kb) Multiome | 1083 | |
| chr6:26,033,113–26,034,309 | 165.6 kb | Distal (>10kb) Multiome | 800 | |
| chr6:26,054,926–26,057,287 | 143.9 kb | Distal (>10kb) Multiome | 1174 | |
| chr6:26,087,383–26,088,017 | 111.6 kb | Distal (>10kb) Multiome | 572 | |
| chr6:26,103,452–26,105,109 | 95.4 kb | Distal (>10kb) Multiome | 1169 | |
| chr6:26,122,481–26,124,909 | 76.3 kb | Distal (>10kb) Multiome HiCAR | 1216 | |
| chr6:26,125,788–26,126,592 | 73.1 kb | Distal (>10kb) Multiome HiCAR | 670 | |
| chr6:26,156,184–26,158,744 | 41.2 kb | Distal (>10kb) Multiome | 1310 | |
| chr6:26,171,798–26,172,499 | 27.3 kb | Distal (>10kb) Multiome | 580 | |
| chr6:26,183,128–26,184,377 | 15.6 kb | Distal (>10kb) Multiome | 311 | |
| chr6:26,187,874–26,189,538 | 10.2 kb | Distal (>10kb) Multiome | 1053 | |
| chr6:26,195,372–26,195,821 | 3.5 kb | Proximal (<10kb) | 512 | |
| chr6:26,196,695–26,197,676 | 2.0 kb | Proximal (<10kb) Multiome | 842 | |
| chr6:26,198,203–26,200,197 | 123 bp | At TSS Multiome | 939 | |
| chr6:26,203,791–26,205,119 | 5.2 kb | Proximal (<10kb) Multiome | 1071 | |
| chr6:26,205,246–26,205,550 | 6.0 kb | Proximal (<10kb) | 612 | |
| chr6:26,205,668–26,206,349 | 6.4 kb | Proximal (<10kb) | 509 | |
| chr6:26,214,872–26,218,468 | 17.6 kb | Distal (>10kb) Multiome | 1096 | |
| chr6:26,223,716–26,224,480 | 24.7 kb | Distal (>10kb) Multiome | 507 | |
| chr6:26,224,856–26,226,566 | 25.9 kb | Distal (>10kb) Multiome | 451 | |
| chr6:26,239,944–26,240,920 | 41.1 kb | Distal (>10kb) Multiome | 375 | |
| chr6:26,249,682–26,251,138 | 51.0 kb | Distal (>10kb) Multiome | 731 | |
| chr6:26,251,339–26,252,079 | 52.5 kb | Distal (>10kb) Multiome | 445 | |
| chr6:26,270,815–26,273,967 | 73.6 kb | Distal (>10kb) Multiome | 742 | |
| chr6:26,285,011–26,286,121 | 86.3 kb | Distal (>10kb) Multiome | 1121 | |
| chr6:26,304,972–26,305,585 | 106.1 kb | Distal (>10kb) Multiome | 586 | |
| chr6:26,312,505–26,313,475 | 113.7 kb | Distal (>10kb) Multiome | 896 | |
| chr6:26,322,092–26,323,232 | 123.4 kb | Distal (>10kb) Multiome | 811 | |
| chr6:26,327,476–26,328,318 | 128.9 kb | Distal (>10kb) Multiome | 716 | |
| chr6:26,341,545–26,342,139 | 142.5 kb | Distal (>10kb) Multiome | 716 | |
| chr6:26,365,073–26,365,647 | 166.0 kb | Distal (>10kb) Multiome | 587 | |
| chr6:26,382,957–26,383,951 | 183.9 kb | Distal (>10kb) Multiome | 448 | |
| chr6:26,421,258–26,421,866 | 222.1 kb | Distal (>10kb) Multiome | 473 | |
| chr6:26,457,390–26,458,395 | 258.6 kb | Distal (>10kb) Multiome | 525 | |
| chr6:26,473,842–26,474,357 | 274.8 kb | Distal (>10kb) Multiome | 487 | |
| chr6:27,131,467–27,132,107 | 932.4 kb | Distal (>10kb) Multiome HiCAR | 580 | |
| chr6:27,132,200–27,134,276 | 933.6 kb | Distal (>10kb) Multiome HiCAR | 975 | |
| chr6:27,139,091–27,140,128 | 940.1 kb | Distal (>10kb) Multiome HiCAR | 662 | |
| chr6:27,145,480–27,148,111 | 947.7 kb | Distal (>10kb) Multiome HiCAR | 951 | |
| chr6:27,806,645–27,808,975 | 1608.7 kb | Distal (>10kb) Multiome HiCAR | 963 | |
| chr6:27,809,816–27,810,576 | 1610.8 kb | Distal (>10kb) Multiome HiCAR | 914 | |
| chr6:27,813,688–27,816,146 | 1615.7 kb | Distal (>10kb) Multiome HiCAR | 564 | |
| chr6:27,836,792–27,839,128 | 1639.2 kb | Distal (>10kb) Multiome HiCAR | 1131 | |
| chr6:27,865,093–27,868,152 | 1666.0 kb | Distal (>10kb) Multiome HiCAR | 744 | |
| chr6:27,870,957–27,872,527 | 1673.0 kb | Distal (>10kb) Multiome HiCAR | 426 | |
| chr6:27,872,808–27,873,995 | 1674.3 kb | Distal (>10kb) Multiome HiCAR | 372 |
Genomic view of the H2AC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.