Transcription factors with Perturb-seq knockdown data for H1-12P. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = H1-12P upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of H1-12P, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:26,187,874–26,189,538 | 6.0 kb | Proximal (<10kb) | 1053 | |
| chr6:26,195,372–26,195,821 | at TSS | At TSS | 512 | |
| chr6:26,196,695–26,197,676 | 1.1 kb | Proximal (<10kb) | 842 | |
| chr6:26,198,203–26,200,197 | 2.6 kb | Proximal (<10kb) | 939 | |
| chr6:26,203,791–26,205,119 | 8.2 kb | Proximal (<10kb) | 1071 | |
| chr6:26,205,246–26,205,550 | 9.7 kb | Proximal (<10kb) | 612 |
Genomic view of the H1-12P locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.