GXYLT1 is a xylosyltransferase (EC 2.4.2.-) that adds the first xylose to O-glucose-modified residues in the epidermal growth factor (EGF; MIM 131530) repeats of proteins such as NOTCH1 (MIM 190198) (Sethi et al., 2010 [PubMed 19940119]).[supplied by OMIM, Mar 2010]
Transcription factors with Perturb-seq knockdown data for GXYLT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GXYLT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GXYLT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:41,933,295–41,934,082 | 211.1 kb | Distal (>10kb) Multiome | 147 | |
| chr12:41,967,605–41,968,483 | 176.6 kb | Distal (>10kb) Multiome | 252 | |
| chr12:42,144,190–42,146,161 | 22 bp | At TSS Multiome | 923 | |
| chr12:42,237,254–42,239,022 | 92.7 kb | Distal (>10kb) Multiome | 833 | |
| chr12:42,325,595–42,326,457 | 181.2 kb | Distal (>10kb) Multiome HiCAR | 748 |
Genomic view of the GXYLT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.