The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for GUCA1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GUCA1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GUCA1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:41,894,347–41,896,221 | 299.6 kb | Distal (>10kb) Multiome | 822 | |
| chr6:41,920,834–41,921,901 | 273.7 kb | Distal (>10kb) Multiome | 955 | |
| chr6:41,940,689–41,942,238 | 253.1 kb | Distal (>10kb) Multiome | 798 | |
| chr6:42,030,637–42,031,169 | 164.0 kb | Distal (>10kb) Multiome | 297 | |
| chr6:42,048,292–42,049,051 | 146.3 kb | Distal (>10kb) Multiome | 627 | |
| chr6:42,050,080–42,050,921 | 144.4 kb | Distal (>10kb) Multiome | 912 | |
| chr6:42,104,179–42,104,979 | 90.5 kb | Distal (>10kb) Multiome | 486 | |
| chr6:42,136,520–42,137,140 | 58.1 kb | Distal (>10kb) Multiome | 555 | |
| chr6:42,142,113–42,142,966 | 52.4 kb | Distal (>10kb) Multiome | 489 | |
| chr6:42,166,489–42,167,048 | 28.2 kb | Distal (>10kb) Multiome | 451 | |
| chr6:42,177,902–42,178,547 | 16.7 kb | Distal (>10kb) Multiome | 161 | |
| chr6:42,260,672–42,261,201 | 66.1 kb | Distal (>10kb) Multiome | 301 | |
| chr6:42,451,208–42,454,840 | 256.9 kb | Distal (>10kb) Multiome | 808 |
Genomic view of the GUCA1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.