Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for GTPBP10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTPBP10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTPBP10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:90,153,881–90,154,994 | 192.2 kb | Distal (>10kb) Multiome | 605 | |
| chr7:90,210,927–90,212,730 | 135.0 kb | Distal (>10kb) Multiome | 843 | |
| chr7:90,223,993–90,224,776 | 122.3 kb | Distal (>10kb) Multiome | 109 | |
| chr7:90,244,257–90,246,748 | 101.5 kb | Distal (>10kb) Multiome | 850 | |
| chr7:90,345,490–90,347,070 | 66 bp | At TSS Multiome | 940 | |
| chr7:90,349,263–90,349,920 | 2.9 kb | Proximal (<10kb) Multiome | 169 | |
| chr7:90,403,221–90,404,177 | 56.8 kb | Distal (>10kb) Multiome | 843 | |
| chr7:90,594,698–90,597,637 | 248.2 kb | Distal (>10kb) Multiome | 788 | |
| chr7:90,621,670–90,622,257 | 275.3 kb | Distal (>10kb) Multiome | 175 |
Genomic view of the GTPBP10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.