Transcription factors with Perturb-seq knockdown data for GTF3C2-AS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF3C2-AS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF3C2-AS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:27,071,223–27,072,896 | 285.4 kb | Distal (>10kb) Multiome | 864 | |
| chr2:27,081,006–27,081,641 | 275.8 kb | Distal (>10kb) Multiome | 758 | |
| chr2:27,085,591–27,087,452 | 270.5 kb | Distal (>10kb) Multiome | 970 | |
| chr2:27,123,498–27,124,089 | 233.4 kb | Distal (>10kb) Multiome | 553 | |
| chr2:27,133,917–27,135,216 | 222.5 kb | Distal (>10kb) Multiome | 815 | |
| chr2:27,211,255–27,212,840 | 145.1 kb | Distal (>10kb) Multiome | 978 | |
| chr2:27,217,045–27,218,005 | 139.8 kb | Distal (>10kb) Multiome | 771 | |
| chr2:27,250,040–27,250,883 | 106.8 kb | Distal (>10kb) Multiome | 559 | |
| chr2:27,262,260–27,263,337 | 94.3 kb | Distal (>10kb) Multiome | 376 | |
| chr2:27,264,406–27,265,326 | 92.1 kb | Distal (>10kb) Multiome | 696 | |
| chr2:27,306,488–27,307,261 | 50.5 kb | Distal (>10kb) Multiome | 115 | |
| chr2:27,322,773–27,323,423 | 34.1 kb | Distal (>10kb) Multiome HiCAR | 906 | |
| chr2:27,356,094–27,357,596 | 233 bp | At TSS Multiome | 1084 | |
| chr2:27,369,685–27,371,261 | 13.2 kb | Distal (>10kb) Multiome | 1096 | |
| chr2:27,380,026–27,381,202 | 23.6 kb | Distal (>10kb) Multiome | 821 | |
| chr2:27,408,972–27,410,056 | 52.5 kb | Distal (>10kb) Multiome | 989 | |
| chr2:27,428,202–27,429,633 | 71.5 kb | Distal (>10kb) Multiome | 1013 | |
| chr2:27,441,811–27,442,884 | 85.2 kb | Distal (>10kb) Multiome | 380 | |
| chr2:27,489,334–27,490,205 | 132.6 kb | Distal (>10kb) Multiome | 731 | |
| chr2:27,494,797–27,495,577 | 138.0 kb | Distal (>10kb) Multiome | 380 | |
| chr2:27,517,085–27,517,958 | 160.4 kb | Distal (>10kb) Multiome | 130 | |
| chr2:27,582,572–27,583,317 | 225.8 kb | Distal (>10kb) Multiome | 843 | |
| chr2:27,628,534–27,629,380 | 271.8 kb | Distal (>10kb) Multiome | 828 |
Genomic view of the GTF3C2-AS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.