This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for GSTZ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSTZ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSTZ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:77,024,027–77,024,710 | 296.6 kb | Distal (>10kb) Multiome | 368 | |
| chr14:77,025,547–77,029,182 | 292.2 kb | Distal (>10kb) Multiome | 996 | |
| chr14:77,032,573–77,034,628 | 287.0 kb | Distal (>10kb) Multiome | 917 | |
| chr14:77,040,063–77,040,913 | 280.5 kb | Distal (>10kb) Multiome | 765 | |
| chr14:77,085,220–77,085,934 | 235.4 kb | Distal (>10kb) Multiome | 132 | |
| chr14:77,088,297–77,088,792 | 232.5 kb | Distal (>10kb) Multiome | 234 | |
| chr14:77,097,312–77,099,236 | 222.9 kb | Distal (>10kb) Multiome | 948 | |
| chr14:77,124,505–77,125,759 | 196.0 kb | Distal (>10kb) Multiome | 289 | |
| chr14:77,139,459–77,142,559 | 181.2 kb | Distal (>10kb) Multiome | 507 | |
| chr14:77,181,185–77,182,207 | 139.3 kb | Distal (>10kb) Multiome | 485 | |
| chr14:77,270,588–77,271,586 | 49.9 kb | Distal (>10kb) Multiome | 147 | |
| chr14:77,313,048–77,313,826 | 7.2 kb | Proximal (<10kb) | 49 | |
| chr14:77,315,816–77,316,379 | 4.6 kb | Proximal (<10kb) | 133 | |
| chr14:77,320,198–77,322,121 | 152 bp | At TSS Multiome | 915 | |
| chr14:77,376,423–77,377,683 | 56.1 kb | Distal (>10kb) Multiome | 630 | |
| chr14:77,456,961–77,458,831 | 136.7 kb | Distal (>10kb) Multiome HiCAR | 878 | |
| chr14:77,498,012–77,499,509 | 177.9 kb | Distal (>10kb) Multiome | 599 | |
| chr14:77,615,862–77,617,380 | 295.8 kb | Distal (>10kb) Multiome | 892 |
Genomic view of the GSTZ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.