This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GRK6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRK6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRK6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:177,131,498–177,134,721 | 293.0 kb | Distal (>10kb) Multiome | 724 | |
| chr5:177,303,008–177,304,238 | 123.0 kb | Distal (>10kb) Multiome | 850 | |
| chr5:177,309,549–177,310,172 | 116.8 kb | Distal (>10kb) Multiome HiCAR | 373 | |
| chr5:177,311,267–177,313,178 | 114.4 kb | Distal (>10kb) Multiome HiCAR | 798 | |
| chr5:177,351,374–177,352,243 | 74.8 kb | Distal (>10kb) Multiome | 832 | |
| chr5:177,362,756–177,363,624 | 63.5 kb | Distal (>10kb) Multiome HiCAR | 479 | |
| chr5:177,366,082–177,368,548 | 59.5 kb | Distal (>10kb) Multiome HiCAR | 626 | |
| chr5:177,370,255–177,371,449 | 55.8 kb | Distal (>10kb) Multiome | 584 | |
| chr5:177,402,327–177,404,671 | 22.2 kb | Distal (>10kb) Multiome | 807 | |
| chr5:177,425,334–177,427,296 | 240 bp | At TSS Multiome | 982 | |
| chr5:177,446,196–177,448,203 | 20.1 kb | Distal (>10kb) Multiome | 826 | |
| chr5:177,453,910–177,456,838 | 28.8 kb | Distal (>10kb) Multiome | 1057 | |
| chr5:177,457,280–177,458,365 | 31.1 kb | Distal (>10kb) Multiome | 321 | |
| chr5:177,472,252–177,474,487 | 46.0 kb | Distal (>10kb) Multiome | 546 | |
| chr5:177,491,301–177,491,987 | 64.9 kb | Distal (>10kb) Multiome | 522 | |
| chr5:177,494,661–177,498,477 | 69.0 kb | Distal (>10kb) Multiome | 915 | |
| chr5:177,500,863–177,501,460 | 74.5 kb | Distal (>10kb) Multiome | 378 | |
| chr5:177,516,515–177,517,551 | 90.4 kb | Distal (>10kb) Multiome | 958 | |
| chr5:177,553,719–177,554,931 | 127.9 kb | Distal (>10kb) Multiome | 671 | |
| chr5:177,591,993–177,592,765 | 165.5 kb | Distal (>10kb) Multiome | 724 | |
| chr5:177,599,409–177,600,500 | 173.4 kb | Distal (>10kb) Multiome | 871 | |
| chr5:177,607,310–177,608,120 | 181.0 kb | Distal (>10kb) Multiome | 392 |
Genomic view of the GRK6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.