This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for GRIK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRIK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRIK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:120,236,598–120,237,182 | 274.9 kb | Distal (>10kb) Multiome | 249 | |
| chr11:120,255,150–120,255,776 | 256.3 kb | Distal (>10kb) Multiome | 143 | |
| chr11:120,324,948–120,325,789 | 186.4 kb | Distal (>10kb) Multiome | 665 | |
| chr11:120,335,703–120,337,153 | 175.4 kb | Distal (>10kb) Multiome | 976 | |
| chr11:120,510,928–120,512,148 | 259 bp | At TSS Multiome | 448 | |
| chr11:120,527,165–120,527,924 | 15.8 kb | Distal (>10kb) Multiome | 168 | |
| chr11:120,564,037–120,565,284 | 52.3 kb | Distal (>10kb) Multiome | 254 | |
| chr11:120,641,483–120,642,081 | 130.0 kb | Distal (>10kb) Multiome HiCAR | 25 | |
| chr11:120,929,398–120,930,110 | 418.0 kb | Distal (>10kb) Multiome HiCAR | 242 | |
| chr11:120,952,870–120,953,318 | 441.3 kb | Distal (>10kb) Multiome HiCAR | 268 |
Genomic view of the GRIK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.