GRID1

glutamate ionotropic receptor delta type subunit 1 | GluD1, KIAA1220

This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]

Biological processes 50 terms

AMPA glutamate receptor activity (GO:0004971)AMPA glutamate receptor complex (GO:0032281)G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential (GO:0099530)GABA receptor activity (GO:0016917)GABA-ergic synapse (GO:0098982)dendritic spine (GO:0043197)extracellular exosome (GO:0070062)glutamatergic synapse (GO:0098978)identical protein binding (GO:0042802)ionotropic glutamate receptor signaling pathway (GO:0035235)ligand-gated monoatomic ion channel activity (GO:0015276)membrane (GO:0016020)modulation of chemical synaptic transmission (GO:0050804)monoatomic ion channel activity (GO:0005216)monoatomic ion transmembrane transport (GO:0034220)monoatomic ion transport (GO:0006811)negative regulation of synaptic plasticity (GO:0031914)phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200)plasma membrane (GO:0005886)postsynaptic density membrane (GO:0098839)postsynaptic density membrane (GO:0098839)postsynaptic density membrane (GO:0098839)postsynaptic membrane (GO:0045211)postsynaptic membrane (GO:0045211)postsynaptic membrane (GO:0045211)postsynaptic membrane (GO:0045211)protein binding (GO:0005515)regulation of postsynapse organization (GO:0099175)regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072)regulation of postsynaptic membrane potential (GO:0060078)regulation of synaptic plasticity (GO:0048167)signal transduction (GO:0007165)signaling receptor activity (GO:0038023)signaling receptor regulator activity (GO:0030545)signaling receptor regulator activity (GO:0030545)social behavior (GO:0035176)social behavior (GO:0035176)synapse (GO:0045202)synapse (GO:0045202)synaptic signaling via neuropeptide (GO:0099538)synaptic signaling via neuropeptide (GO:0099538)synaptic signaling via neuropeptide (GO:0099538)synaptic transmission, glutamatergic (GO:0035249)trans-synaptic protein complex (GO:0098820)trans-synaptic protein complex (GO:0098820)trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission (GO:0099557)trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission (GO:0099557)transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315)transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315)transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315)

Expression (TPM)

TFs regulating GRID1 0 TFs

Transcription factors with Perturb-seq knockdown data for GRID1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRID1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GRID1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRID1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:84,540,397–84,541,691	1072.3 kb	Distal (>10kb) Multiome HiCAR	470
chr10:84,613,216–84,614,226	999.4 kb	Distal (>10kb) Multiome HiCAR	287
chr10:85,420,496–85,421,149	192.2 kb	Distal (>10kb) Multiome	131
chr10:85,492,595–85,493,489	120.2 kb	Distal (>10kb) Multiome	202
chr10:86,362,777–86,364,049	750.1 kb	Distal (>10kb) Multiome	244
chr10:86,364,597–86,365,352	1.4 kb	Proximal (<10kb)	115
chr10:86,365,694–86,367,849	753.6 kb	Distal (>10kb) Multiome	419
chr10:86,376,705–86,377,696	764.2 kb	Distal (>10kb) Multiome HiCAR	545
chr10:86,389,055–86,390,403	776.6 kb	Distal (>10kb) Multiome	377
chr10:86,399,617–86,401,886	787.0 kb	Distal (>10kb) Multiome	946
chr10:86,520,920–86,522,476	908.7 kb	Distal (>10kb) Multiome	901
chr10:86,535,238–86,536,949	922.4 kb	Distal (>10kb) Multiome	617
chr10:86,585,119–86,585,766	972.5 kb	Distal (>10kb) Multiome	421
chr10:86,599,659–86,600,297	986.8 kb	Distal (>10kb) Multiome	111
chr10:86,631,854–86,632,698	1019.1 kb	Distal (>10kb) Multiome	226

Genome Browser

Genomic view of the GRID1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.