Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in endoplasmic reticulum-plasma membrane tethering and regulation of store-operated calcium entry. Located in endoplasmic reticulum membrane; organelle membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GRAMD2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRAMD2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRAMD2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:72,116,889–72,118,908 | 79.6 kb | Distal (>10kb) Multiome | 885 | |
| chr15:72,193,705–72,194,172 | 3.6 kb | Proximal (<10kb) | 34 | |
| chr15:72,195,221–72,195,692 | 2.1 kb | Proximal (<10kb) | 120 | |
| chr15:72,196,452–72,198,720 | 104 bp | At TSS Multiome | 458 | |
| chr15:72,199,778–72,200,036 | 2.0 kb | Proximal (<10kb) | 320 | |
| chr15:72,226,391–72,227,225 | 29.1 kb | Distal (>10kb) Multiome | 515 | |
| chr15:72,229,966–72,232,028 | 33.6 kb | Distal (>10kb) Multiome | 1128 | |
| chr15:72,242,418–72,243,365 | 45.2 kb | Distal (>10kb) Multiome | 236 | |
| chr15:72,271,919–72,273,237 | 75.0 kb | Distal (>10kb) Multiome | 687 | |
| chr15:72,319,497–72,320,675 | 122.3 kb | Distal (>10kb) Multiome | 632 | |
| chr15:72,375,551–72,376,566 | 178.2 kb | Distal (>10kb) Multiome | 1074 | |
| chr15:72,473,670–72,475,497 | 276.4 kb | Distal (>10kb) Multiome | 1105 |
Genomic view of the GRAMD2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.