GPS1

G protein pathway suppressor 1 | COPS1, CSN1

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]

Member of: DE-1 Developmental clusters: GC7

Biological processes 17 terms

COP9 signalosome (GO:0008180)COP9 signalosome (GO:0008180)COP9 signalosome (GO:0008180)GTPase inhibitor activity (GO:0005095)JNK cascade (GO:0007254)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein deneddylation (GO:0000338)protein neddylation (GO:0045116)regulation of protein neddylation (GO:2000434)

Expression (TPM)

TFs regulating GPS1 0 TFs

Transcription factors with Perturb-seq knockdown data for GPS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GPS1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:81,832,473–81,833,976	218.6 kb	Distal (>10kb) Multiome	1015
chr17:81,859,762–81,861,595	191.0 kb	Distal (>10kb) Multiome	1134
chr17:81,868,421–81,868,978	183.3 kb	Distal (>10kb) Multiome	577
chr17:81,869,000–81,872,289	180.6 kb	Distal (>10kb) Multiome	1136
chr17:81,891,143–81,892,257	160.1 kb	Distal (>10kb) Multiome	969
chr17:81,910,443–81,911,980	140.3 kb	Distal (>10kb) Multiome	806
chr17:81,917,586–81,918,522	133.7 kb	Distal (>10kb) Multiome	619
chr17:81,923,285–81,923,863	128.4 kb	Distal (>10kb) Multiome	399
chr17:81,926,141–81,929,133	124.0 kb	Distal (>10kb) Multiome	1034
chr17:81,936,855–81,937,682	114.6 kb	Distal (>10kb) Multiome	854
chr17:81,959,299–81,962,169	92.2 kb	Distal (>10kb) Multiome	805
chr17:81,966,804–81,968,359	83.8 kb	Distal (>10kb) Multiome	908
chr17:81,976,595–81,978,312	74.2 kb	Distal (>10kb) Multiome	1001
chr17:82,019,856–82,020,391	31.8 kb	Distal (>10kb) Multiome	436
chr17:82,022,355–82,024,111	28.8 kb	Distal (>10kb) Multiome	898
chr17:82,029,976–82,032,662	20.0 kb	Distal (>10kb) Multiome	695
chr17:82,036,902–82,037,961	14.3 kb	Distal (>10kb) Multiome	892
chr17:82,051,387–82,052,184	120 bp	At TSS Multiome	479
chr17:82,065,558–82,066,150	13.9 kb	Distal (>10kb) Multiome	967
chr17:82,096,478–82,100,203	46.7 kb	Distal (>10kb) Multiome	1085
chr17:82,103,334–82,104,356	51.7 kb	Distal (>10kb) Multiome	672
chr17:82,212,405–82,213,592	161.0 kb	Distal (>10kb) Multiome	911
chr17:82,228,266–82,232,536	177.1 kb	Distal (>10kb) Multiome	1048
chr17:82,272,608–82,274,062	221.8 kb	Distal (>10kb) Multiome	943
chr17:82,278,488–82,279,226	227.0 kb	Distal (>10kb) Multiome	229
chr17:82,292,400–82,293,256	241.0 kb	Distal (>10kb) Multiome	944

Genome Browser

Genomic view of the GPS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.