This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GPR180. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR180 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR180, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:94,302,944–94,304,409 | 298.5 kb | Distal (>10kb) Multiome | 284 | |
| chr13:94,416,490–94,416,986 | 185.1 kb | Distal (>10kb) Multiome | 200 | |
| chr13:94,548,604–94,550,382 | 52.3 kb | Distal (>10kb) Multiome | 899 | |
| chr13:94,595,700–94,596,749 | 5.6 kb | Proximal (<10kb) Multiome | 741 | |
| chr13:94,601,312–94,602,589 | 24 bp | At TSS Multiome | 663 | |
| chr13:94,707,389–94,708,611 | 106.4 kb | Distal (>10kb) Multiome | 257 | |
| chr13:94,710,520–94,714,056 | 111.5 kb | Distal (>10kb) Multiome | 498 | |
| chr13:94,825,487–94,826,097 | 223.9 kb | Distal (>10kb) Multiome | 148 |
Genomic view of the GPR180 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.