G protein-coupled receptors (GPCRs) are a large superfamily of cell surface receptors characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains.[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for GPR156. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR156 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR156, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:120,093,804–120,096,088 | 190.4 kb | Distal (>10kb) Multiome | 1114 | |
| chr3:120,284,858–120,285,627 | 73 bp | At TSS Multiome | 237 | |
| chr3:120,348,500–120,350,077 | 64.0 kb | Distal (>10kb) Multiome | 1003 | |
| chr3:120,416,932–120,417,959 | 132.2 kb | Distal (>10kb) Multiome | 482 | |
| chr3:120,450,045–120,452,154 | 165.9 kb | Distal (>10kb) Multiome | 496 |
Genomic view of the GPR156 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.