Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of cholesterol biosynthetic process. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPR146. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR146 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR146, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:815,511–817,550 | 228.2 kb | Distal (>10kb) Multiome | 640 | |
| chr7:875,946–877,507 | 168.0 kb | Distal (>10kb) Multiome | 918 | |
| chr7:901,112–902,113 | 142.9 kb | Distal (>10kb) Multiome | 376 | |
| chr7:953,606–955,017 | 90.0 kb | Distal (>10kb) Multiome | 482 | |
| chr7:974,909–975,889 | 69.0 kb | Distal (>10kb) Multiome | 860 | |
| chr7:992,812–993,637 | 51.2 kb | Distal (>10kb) Multiome | 824 | |
| chr7:1,028,063–1,028,589 | 16.2 kb | Distal (>10kb) Multiome | 503 | |
| chr7:1,044,102–1,045,027 | 49 bp | At TSS Multiome | 715 | |
| chr7:1,059,302–1,060,226 | 15.2 kb | Distal (>10kb) Multiome | 156 | |
| chr7:1,137,933–1,138,672 | 93.8 kb | Distal (>10kb) Multiome | 673 | |
| chr7:1,159,935–1,160,583 | 115.8 kb | Distal (>10kb) Multiome | 746 | |
| chr7:1,235,892–1,237,020 | 191.9 kb | Distal (>10kb) Multiome | 184 |
Genomic view of the GPR146 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.