Involved in positive regulation of TORC1 signaling; positive regulation of protein localization to lysosome; and regulation of autophagy. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPR137B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR137B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR137B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:235,866,120–235,867,793 | 275.5 kb | Distal (>10kb) Multiome | 845 | |
| chr1:235,971,561–235,972,553 | 170.5 kb | Distal (>10kb) Multiome | 595 | |
| chr1:236,063,919–236,065,936 | 77.3 kb | Distal (>10kb) Multiome | 930 | |
| chr1:236,140,574–236,141,829 | 674 bp | At TSS | 321 | |
| chr1:236,141,986–236,143,622 | 212 bp | At TSS Multiome | 517 | |
| chr1:236,280,771–236,282,629 | 139.6 kb | Distal (>10kb) Multiome | 881 | |
| chr1:236,394,885–236,396,208 | 253.0 kb | Distal (>10kb) Multiome HiCAR | 588 |
Genomic view of the GPR137B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.