This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GOSR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOSR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOSR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:30,291,554–30,292,527 | 185.3 kb | Distal (>10kb) Multiome | 724 | |
| chr17:30,340,166–30,340,693 | 136.9 kb | Distal (>10kb) Multiome | 394 | |
| chr17:30,378,665–30,379,625 | 98.5 kb | Distal (>10kb) Multiome | 693 | |
| chr17:30,477,182–30,477,726 | 33 bp | At TSS Multiome | 903 | |
| chr17:30,599,655–30,601,277 | 123.0 kb | Distal (>10kb) Multiome | 793 | |
| chr17:30,707,918–30,709,425 | 231.2 kb | Distal (>10kb) Multiome | 471 | |
| chr17:30,731,337–30,732,077 | 254.2 kb | Distal (>10kb) Multiome | 352 |
Genomic view of the GOSR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.