The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for GORASP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GORASP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GORASP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:39,051,625–39,052,625 | 55.5 kb | Distal (>10kb) Multiome | 881 | |
| chr3:39,101,187–39,101,387 | 6.2 kb | Proximal (<10kb) | 147 | |
| chr3:39,106,596–39,108,201 | 16 bp | At TSS Multiome | 754 | |
| chr3:39,150,367–39,155,021 | 47.1 kb | Distal (>10kb) Multiome | 1014 | |
| chr3:39,177,458–39,178,406 | 70.4 kb | Distal (>10kb) Multiome | 531 | |
| chr3:39,180,469–39,181,324 | 73.4 kb | Distal (>10kb) Multiome HiCAR | 541 | |
| chr3:39,288,216–39,288,885 | 180.9 kb | Distal (>10kb) Multiome HiCAR | 463 | |
| chr3:39,404,841–39,405,400 | 297.4 kb | Distal (>10kb) Multiome | 137 | |
| chr3:39,406,328–39,407,246 | 299.0 kb | Distal (>10kb) Multiome | 1019 |
Genomic view of the GORASP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.