Transcription factors with Perturb-seq knockdown data for GLUD1P2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLUD1P2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLUD1P2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:46,228,286–46,229,571 | 557.3 kb | Distal (>10kb) Multiome HiCAR | 447 | |
| chr10:46,540,658–46,543,680 | 245.4 kb | Distal (>10kb) Multiome | 351 | |
| chr10:46,555,197–46,559,190 | 230.4 kb | Distal (>10kb) Multiome | 519 | |
| chr10:46,786,694–46,787,119 | at TSS | At TSS | 270 | |
| chr10:47,553,175–47,553,705 | 766.7 kb | Distal (>10kb) Multiome HiCAR | 425 |
Genomic view of the GLUD1P2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.