This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for GIPR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GIPR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GIPR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:45,657,897–45,658,235 | 10.0 kb | Proximal (<10kb) | 200 | |
| chr19:45,667,856–45,668,417 | at TSS | At TSS | 386 | |
| chr19:45,668,914–45,669,719 | 694 bp | At TSS | 611 | |
| chr19:45,670,481–45,671,446 | 2.3 kb | Proximal (<10kb) | 361 | |
| chr19:45,676,875–45,678,209 | 8.7 kb | Proximal (<10kb) | 418 | |
| chr19:45,681,530–45,682,004 | 4.0 kb | Proximal (<10kb) | 648 |
Genomic view of the GIPR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.