This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GINS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GINS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GINS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:58,128,725–58,130,027 | 263.2 kb | Distal (>10kb) Multiome | 1095 | |
| chr16:58,197,509–58,198,705 | 194.5 kb | Distal (>10kb) Multiome | 490 | |
| chr16:58,236,247–58,236,852 | 156.1 kb | Distal (>10kb) Multiome | 355 | |
| chr16:58,249,584–58,250,557 | 142.7 kb | Distal (>10kb) Multiome | 641 | |
| chr16:58,392,269–58,393,124 | 65 bp | At TSS Multiome | 993 | |
| chr16:58,463,143–58,465,363 | 71.0 kb | Distal (>10kb) Multiome | 307 | |
| chr16:58,487,547–58,488,283 | 95.2 kb | Distal (>10kb) Multiome HiCAR | 523 | |
| chr16:58,499,699–58,500,457 | 107.3 kb | Distal (>10kb) Multiome | 283 | |
| chr16:58,500,548–58,502,121 | 108.8 kb | Distal (>10kb) Multiome | 481 | |
| chr16:58,511,772–58,512,394 | 119.4 kb | Distal (>10kb) Multiome | 355 | |
| chr16:58,515,027–58,516,681 | 122.9 kb | Distal (>10kb) Multiome | 1010 | |
| chr16:58,629,310–58,630,709 | 237.5 kb | Distal (>10kb) Multiome | 1050 | |
| chr16:58,684,159–58,685,101 | 292.0 kb | Distal (>10kb) Multiome | 695 |
Genomic view of the GINS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.