Predicted to enable nucleic acid binding activity. Predicted to be involved in DNA integration. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:102,753,823–102,756,422 | 365.0 kb | Distal (>10kb) Multiome HiCAR | 821 | |
| chr5:102,865,225–102,866,661 | 254.3 kb | Distal (>10kb) Multiome | 621 | |
| chr5:103,119,392–103,121,169 | 66 bp | At TSS Multiome | 1050 | |
| chr5:103,223,049–103,225,117 | 104.6 kb | Distal (>10kb) Multiome | 339 | |
| chr5:103,243,524–103,244,857 | 123.9 kb | Distal (>10kb) Multiome | 129 | |
| chr5:103,258,219–103,260,199 | 138.5 kb | Distal (>10kb) Multiome | 874 |
Genomic view of the GIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.