Predicted to enable glycerophosphodiester phosphodiesterase activity. Predicted to be involved in positive regulation of cell cycle and positive regulation of neuron differentiation. Predicted to act upstream of or within negative regulation of Notch signaling pathway; neuron differentiation; and regulation of timing of cell differentiation. Predicted to be located in axon; neuronal cell body; and perinuclear endoplasmic reticulum. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for GDPD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GDPD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GDPD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:75,240,428–75,242,358 | 284.1 kb | Distal (>10kb) Multiome | 618 | |
| chr11:75,331,054–75,332,820 | 193.7 kb | Distal (>10kb) Multiome | 273 | |
| chr11:75,343,281–75,343,976 | 182.2 kb | Distal (>10kb) Multiome | 375 | |
| chr11:75,351,219–75,352,738 | 173.6 kb | Distal (>10kb) Multiome | 868 | |
| chr11:75,388,579–75,389,156 | 137.0 kb | Distal (>10kb) Multiome | 323 | |
| chr11:75,399,325–75,400,051 | 126.3 kb | Distal (>10kb) Multiome | 982 | |
| chr11:75,425,349–75,425,850 | 100.2 kb | Distal (>10kb) Multiome | 134 | |
| chr11:75,427,839–75,428,742 | 97.5 kb | Distal (>10kb) Multiome | 209 | |
| chr11:75,429,695–75,430,823 | 95.6 kb | Distal (>10kb) Multiome | 340 | |
| chr11:75,524,766–75,526,517 | 159 bp | At TSS Multiome | 663 | |
| chr11:75,532,236–75,532,651 | 6.4 kb | Proximal (<10kb) | 275 | |
| chr11:75,547,627–75,548,081 | 21.9 kb | Distal (>10kb) Multiome | 241 | |
| chr11:75,554,271–75,554,862 | 28.7 kb | Distal (>10kb) Multiome | 441 | |
| chr11:75,559,107–75,559,968 | 33.7 kb | Distal (>10kb) Multiome | 262 | |
| chr11:75,561,674–75,564,448 | 36.4 kb | Distal (>10kb) Multiome | 813 | |
| chr11:75,582,925–75,584,268 | 58.0 kb | Distal (>10kb) Multiome | 489 | |
| chr11:75,667,242–75,669,059 | 141.8 kb | Distal (>10kb) Multiome | 328 | |
| chr11:75,768,053–75,769,178 | 242.8 kb | Distal (>10kb) Multiome | 885 | |
| chr11:75,780,954–75,781,467 | 255.3 kb | Distal (>10kb) Multiome | 37 | |
| chr11:75,814,230–75,815,903 | 289.2 kb | Distal (>10kb) Multiome | 814 |
Genomic view of the GDPD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.