Transcription factors with Perturb-seq knockdown data for GATA2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GATA2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GATA2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:128,486,731–128,487,080 | 2.1 kb | Proximal (<10kb) | 273 | |
| chr3:128,487,682–128,488,679 | 531 bp | At TSS | 710 | |
| chr3:128,488,798–128,489,787 | at TSS | At TSS | 515 | |
| chr3:128,489,907–128,490,591 | 696 bp | At TSS | 413 | |
| chr3:128,492,255–128,493,190 | 3.0 kb | Proximal (<10kb) | 270 | |
| chr3:128,497,309–128,498,144 | 8.1 kb | Proximal (<10kb) | 464 |
Genomic view of the GATA2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.