Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for GASK1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GASK1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GASK1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:42,772,623–42,773,428 | 206.1 kb | Distal (>10kb) Multiome | 446 | |
| chr3:42,803,822–42,804,944 | 174.8 kb | Distal (>10kb) Multiome | 881 | |
| chr3:42,880,478–42,881,506 | 98.2 kb | Distal (>10kb) Multiome | 685 | |
| chr3:42,979,048–42,979,795 | 135 bp | At TSS Multiome | 351 | |
| chr3:43,105,389–43,106,477 | 126.8 kb | Distal (>10kb) Multiome | 588 |
Genomic view of the GASK1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.