This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Transcription factors with Perturb-seq knockdown data for GAS8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAS8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAS8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:89,720,440–89,722,486 | 298.3 kb | Distal (>10kb) Multiome | 1048 | |
| chr16:89,816,022–89,817,100 | 202.9 kb | Distal (>10kb) Multiome | 995 | |
| chr16:89,827,667–89,829,190 | 191.2 kb | Distal (>10kb) Multiome | 784 | |
| chr16:89,872,618–89,874,723 | 145.4 kb | Distal (>10kb) Multiome | 1046 | |
| chr16:89,917,809–89,919,023 | 101.0 kb | Distal (>10kb) Multiome | 986 | |
| chr16:89,921,530–89,925,204 | 96.4 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:89,925,437–89,926,738 | 93.4 kb | Distal (>10kb) Multiome | 654 | |
| chr16:89,972,039–89,973,313 | 46.9 kb | Distal (>10kb) Multiome | 965 | |
| chr16:90,018,651–90,020,274 | 14 bp | At TSS Multiome | 634 | |
| chr16:90,046,432–90,047,827 | 27.3 kb | Distal (>10kb) Multiome | 700 | |
| chr16:90,077,247–90,078,026 | 57.8 kb | Distal (>10kb) Multiome | 412 | |
| chr16:90,081,997–90,082,775 | 62.6 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the GAS8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.