The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for GAS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:22,340,758–22,341,768 | 284.5 kb | Distal (>10kb) Multiome | 166 | |
| chr11:22,342,578–22,344,429 | 282.0 kb | Distal (>10kb) Multiome | 210 | |
| chr11:22,432,134–22,433,214 | 193.0 kb | Distal (>10kb) Multiome | 266 | |
| chr11:22,528,402–22,529,293 | 96.8 kb | Distal (>10kb) Multiome | 128 | |
| chr11:22,617,807–22,618,190 | 7.5 kb | Proximal (<10kb) | 5 | |
| chr11:22,624,646–22,626,344 | 80 bp | At TSS Multiome | 909 | |
| chr11:22,634,936–22,636,595 | 9.3 kb | Proximal (<10kb) | 521 | |
| chr11:22,656,978–22,657,777 | 9.3 kb | Proximal (<10kb) | 130 | |
| chr11:22,666,027–22,667,470 | 41.3 kb | Distal (>10kb) Multiome | 532 | |
| chr11:22,670,925–22,671,095 | 3.9 kb | Proximal (<10kb) | 77 | |
| chr11:22,829,227–22,830,360 | 204.2 kb | Distal (>10kb) Multiome | 805 | |
| chr11:22,922,303–22,923,887 | 297.3 kb | Distal (>10kb) Multiome | 194 |
Genomic view of the GAS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.