Predicted to be involved in defense response to virus; innate immune response; and positive regulation of type I interferon production. Predicted to act upstream of or within several processes, including flagellated sperm motility; penetration of zona pellucida; and spermatid development. Predicted to be located in Golgi apparatus. Predicted to be active in sperm head. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GARIN5A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GARIN5A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GARIN5A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:50,203,034–50,204,072 | 272.8 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,205,195–50,205,903 | 270.9 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,311,942–50,312,908 | 164.0 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,313,900–50,314,529 | 162.1 kb | Distal (>10kb) Multiome | 114 | |
| chr19:50,315,313–50,316,408 | 160.3 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,325,322–50,326,594 | 150.5 kb | Distal (>10kb) Multiome | 748 | |
| chr19:50,328,019–50,330,066 | 147.0 kb | Distal (>10kb) Multiome | 699 | |
| chr19:50,330,341–50,331,411 | 145.4 kb | Distal (>10kb) Multiome | 479 | |
| chr19:50,332,395–50,334,325 | 142.8 kb | Distal (>10kb) Multiome | 907 | |
| chr19:50,368,630–50,369,092 | 107.3 kb | Distal (>10kb) Multiome | 311 | |
| chr19:50,376,225–50,377,452 | 99.4 kb | Distal (>10kb) Multiome | 931 | |
| chr19:50,383,444–50,384,805 | 92.1 kb | Distal (>10kb) Multiome | 863 | |
| chr19:50,414,638–50,415,204 | 61.4 kb | Distal (>10kb) Multiome | 377 | |
| chr19:50,431,430–50,432,503 | 44.4 kb | Distal (>10kb) Multiome | 530 | |
| chr19:50,475,914–50,477,044 | 158 bp | At TSS Multiome | 622 | |
| chr19:50,510,707–50,511,948 | 35.0 kb | Distal (>10kb) Multiome | 794 | |
| chr19:50,556,266–50,557,084 | 80.5 kb | Distal (>10kb) Multiome | 463 | |
| chr19:50,639,246–50,640,210 | 163.4 kb | Distal (>10kb) Multiome | 326 | |
| chr19:50,657,814–50,659,557 | 183.0 kb | Distal (>10kb) Multiome | 790 | |
| chr19:50,723,765–50,725,772 | 248.6 kb | Distal (>10kb) Multiome | 721 | |
| chr19:50,728,202–50,728,738 | 252.2 kb | Distal (>10kb) Multiome | 345 |
Genomic view of the GARIN5A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.