Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GALNTL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GALNTL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GALNTL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:170,089,100–170,090,754 | 1723.3 kb | Distal (>10kb) Multiome HiCAR | 761 | |
| chr4:170,259,234–170,260,354 | 1553.6 kb | Distal (>10kb) Multiome HiCAR | 326 | |
| chr4:170,681,492–170,683,245 | 1131.1 kb | Distal (>10kb) Multiome HiCAR | 231 | |
| chr4:171,812,184–171,815,057 | at TSS | At TSS | 399 | |
| chr4:171,983,891–171,984,947 | 171.2 kb | Distal (>10kb) Multiome | 156 |
Genomic view of the GALNTL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.