GADD45GIP1

GADD45G interacting protein 1 | CKBBP2, CKbetaBP2, CRIF1, MGC4667, MGC4758, PLINP-1, PRG6, Plinp1, mL64

This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]

Member of: DE-1

Biological processes 13 terms

mitochondrial inner membrane (GO:0005743)mitochondrial large ribosomal subunit (GO:0005762)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial translation (GO:0032543)mitochondrial translation (GO:0032543)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)nucleus (GO:0005634)protein binding (GO:0005515)structural constituent of ribosome (GO:0003735)

Expression (TPM)

TFs regulating GADD45GIP1 0 TFs

Transcription factors with Perturb-seq knockdown data for GADD45GIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GADD45GIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GADD45GIP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GADD45GIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,656,871–12,657,566	300.0 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	290.5 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	287.7 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	275.8 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	260.6 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	254.0 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	234.8 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	233.1 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	222.5 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	220.1 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	199.4 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	191.0 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	181.8 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	179.3 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	174.5 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	167.2 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	165.7 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	163.5 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	155.3 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	150.7 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	131.4 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	124.6 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	123.3 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	118.8 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	116.4 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	109.5 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	89.6 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	83.9 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	75.7 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	71.8 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	66.2 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	43.9 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	37.8 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	23.5 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	18.8 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	11.3 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	3 bp	At TSS Multiome	747
chr19:12,964,998–12,965,862	8.2 kb	Proximal (<10kb) Multiome	733
chr19:12,983,506–12,983,997	26.5 kb	Distal (>10kb) Multiome	688
chr19:13,051,485–13,052,169	94.6 kb	Distal (>10kb) Multiome	649
chr19:13,061,195–13,061,672	104.3 kb	Distal (>10kb) Multiome HiCAR	544
chr19:13,069,469–13,070,306	112.6 kb	Distal (>10kb) Multiome HiCAR	334
chr19:13,093,620–13,094,260	136.7 kb	Distal (>10kb) Multiome	411
chr19:13,095,079–13,096,870	138.2 kb	Distal (>10kb) Multiome	501
chr19:13,102,495–13,103,074	145.6 kb	Distal (>10kb) Multiome HiCAR	606
chr19:13,116,411–13,117,080	159.5 kb	Distal (>10kb) Multiome	812
chr19:13,117,979–13,119,416	161.0 kb	Distal (>10kb) Multiome	699
chr19:13,149,468–13,156,577	193.1 kb	Distal (>10kb) Multiome	1333
chr19:13,162,579–13,165,523	207.5 kb	Distal (>10kb) Multiome	1112
chr19:13,167,359–13,168,023	210.5 kb	Distal (>10kb) Multiome	764

Genome Browser

Genomic view of the GADD45GIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.