This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GADD45G. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GADD45G upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GADD45G, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:89,310,238–89,311,866 | 294.0 kb | Distal (>10kb) Multiome | 945 | |
| chr9:89,317,972–89,319,093 | 286.4 kb | Distal (>10kb) Multiome | 1083 | |
| chr9:89,497,231–89,498,509 | 106.9 kb | Distal (>10kb) Multiome | 374 | |
| chr9:89,598,196–89,598,386 | 6.6 kb | Proximal (<10kb) | 105 | |
| chr9:89,603,012–89,604,575 | 1.9 kb | Proximal (<10kb) Multiome | 537 | |
| chr9:89,604,751–89,607,232 | 1.8 kb | Proximal (<10kb) Multiome | 689 | |
| chr9:89,661,587–89,662,555 | 57.1 kb | Distal (>10kb) Multiome HiCAR | 313 | |
| chr9:89,675,046–89,675,613 | 70.3 kb | Distal (>10kb) Multiome | 98 | |
| chr9:89,705,274–89,706,387 | 100.8 kb | Distal (>10kb) Multiome HiCAR | 54 |
Genomic view of the GADD45G locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.