This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for G6PD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = G6PD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of G6PD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:154,368,993–154,370,053 | 177.3 kb | Distal (>10kb) Multiome | 546 | |
| chrX:154,370,757–154,372,188 | 175.5 kb | Distal (>10kb) Multiome | 764 | |
| chrX:154,378,063–154,379,701 | 167.9 kb | Distal (>10kb) Multiome | 687 | |
| chrX:154,397,430–154,398,941 | 148.7 kb | Distal (>10kb) Multiome | 871 | |
| chrX:154,409,052–154,409,671 | 137.5 kb | Distal (>10kb) Multiome | 396 | |
| chrX:154,428,419–154,428,969 | 118.3 kb | Distal (>10kb) Multiome | 601 | |
| chrX:154,436,501–154,437,435 | 110.0 kb | Distal (>10kb) Multiome | 448 | |
| chrX:154,443,986–154,444,454 | 102.7 kb | Distal (>10kb) Multiome | 329 | |
| chrX:154,457,605–154,458,763 | 88.8 kb | Distal (>10kb) Multiome | 467 | |
| chrX:154,478,385–154,479,590 | 67.8 kb | Distal (>10kb) Multiome | 707 | |
| chrX:154,486,385–154,487,035 | 60.1 kb | Distal (>10kb) Multiome | 437 | |
| chrX:154,490,259–154,491,245 | 56.1 kb | Distal (>10kb) Multiome | 567 | |
| chrX:154,515,811–154,517,059 | 30.5 kb | Distal (>10kb) Multiome | 590 | |
| chrX:154,546,514–154,547,906 | 317 bp | At TSS Multiome | 691 | |
| chrX:154,762,385–154,763,339 | 215.9 kb | Distal (>10kb) Multiome | 675 | |
| chrX:154,805,199–154,805,850 | 258.6 kb | Distal (>10kb) Multiome | 481 |
Genomic view of the G6PD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.