This gene encodes the catalytic subunit of glucose-6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways. Mutations in this gene result in autosomal recessive severe congenital neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for G6PC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = G6PC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of G6PC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:43,778,079–43,779,460 | 292.1 kb | Distal (>10kb) Multiome | 937 | |
| chr17:43,832,658–43,833,385 | 237.7 kb | Distal (>10kb) Multiome | 455 | |
| chr17:43,900,207–43,900,990 | 170.2 kb | Distal (>10kb) Multiome | 308 | |
| chr17:43,906,025–43,906,856 | 164.3 kb | Distal (>10kb) Multiome | 353 | |
| chr17:43,907,081–43,907,899 | 163.1 kb | Distal (>10kb) Multiome | 362 | |
| chr17:43,937,932–43,938,382 | 132.7 kb | Distal (>10kb) Multiome | 757 | |
| chr17:43,952,298–43,953,752 | 117.8 kb | Distal (>10kb) Multiome | 295 | |
| chr17:43,983,489–43,984,364 | 86.8 kb | Distal (>10kb) Multiome | 743 | |
| chr17:44,004,236–44,007,875 | 66.2 kb | Distal (>10kb) Multiome | 807 | |
| chr17:44,014,255–44,015,168 | 56.0 kb | Distal (>10kb) Multiome | 1020 | |
| chr17:44,066,017–44,066,857 | 4.3 kb | Proximal (<10kb) Multiome | 722 | |
| chr17:44,070,107–44,071,340 | 96 bp | At TSS Multiome | 1041 | |
| chr17:44,095,480–44,096,263 | 25.1 kb | Distal (>10kb) Multiome | 713 | |
| chr17:44,110,949–44,111,605 | 40.4 kb | Distal (>10kb) Multiome | 856 | |
| chr17:44,122,999–44,124,340 | 52.9 kb | Distal (>10kb) Multiome | 883 | |
| chr17:44,141,505–44,142,741 | 71.0 kb | Distal (>10kb) Multiome | 857 | |
| chr17:44,168,259–44,168,849 | 97.7 kb | Distal (>10kb) Multiome | 475 | |
| chr17:44,186,111–44,187,514 | 116.0 kb | Distal (>10kb) Multiome | 917 | |
| chr17:44,198,550–44,201,037 | 129.3 kb | Distal (>10kb) Multiome | 868 | |
| chr17:44,210,257–44,210,930 | 139.7 kb | Distal (>10kb) Multiome | 568 | |
| chr17:44,218,107–44,221,629 | 147.8 kb | Distal (>10kb) Multiome | 936 | |
| chr17:44,221,765–44,222,816 | 151.4 kb | Distal (>10kb) Multiome | 597 | |
| chr17:44,307,755–44,309,164 | 237.6 kb | Distal (>10kb) Multiome | 726 | |
| chr17:44,314,945–44,315,776 | 244.4 kb | Distal (>10kb) Multiome | 273 | |
| chr17:44,316,273–44,316,728 | 245.6 kb | Distal (>10kb) Multiome | 183 | |
| chr17:44,324,218–44,325,841 | 254.0 kb | Distal (>10kb) Multiome | 852 | |
| chr17:44,326,610–44,327,149 | 256.1 kb | Distal (>10kb) Multiome | 599 | |
| chr17:44,344,826–44,346,001 | 274.3 kb | Distal (>10kb) Multiome | 837 | |
| chr17:44,353,667–44,355,182 | 283.9 kb | Distal (>10kb) Multiome | 393 | |
| chr17:44,363,447–44,364,077 | 293.0 kb | Distal (>10kb) Multiome | 502 |
Genomic view of the G6PC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.