This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for FXYD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FXYD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FXYD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:117,816,894–117,818,195 | 59.0 kb | Distal (>10kb) Multiome | 420 | |
| chr11:117,876,319–117,877,092 | 17 bp | At TSS Multiome | 258 | |
| chr11:117,907,190–117,907,664 | 30.7 kb | Distal (>10kb) Multiome | 334 | |
| chr11:117,985,878–117,986,675 | 109.6 kb | Distal (>10kb) Multiome | 594 | |
| chr11:118,145,213–118,146,237 | 268.9 kb | Distal (>10kb) Multiome | 567 | |
| chr11:118,152,392–118,153,276 | 276.2 kb | Distal (>10kb) Multiome | 297 | |
| chr11:118,171,543–118,172,070 | 295.1 kb | Distal (>10kb) Multiome | 332 |
Genomic view of the FXYD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.